WINTER IS COMING

Cognitive & Neurological Support

1 / 2

Peptides Line

NAD+

Name: NAD+
Brand: Peptalon
SKU: PE-0029-02-1000
Availability: InStock
Rating: 4.8 (127 reviews)

NAD⁺ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme involved in energy production, DNA repair, and cellular metabolism.

From 60,00 €

format:

Key Ingredients

Nicotinamide Adenine Dinucleotide (oxidized form)

Better Mental Recovery

Neuroprotection

Boosts Mitochondria

Promotes DNA Repair

Anti inflammatory

Enhances Fat Oxidation

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

NAD⁺ is a naturally occurring coenzyme found in every living cell, essential for converting food into energy, repairing DNA, and regulating cell survival. NAD⁺ plays a central role in mitochondrial function, oxidative stress control, and activating key longevity genes such as sirtuins.NAD⁺ levels decline sharply with age, contributing to fatigue, cognitive decline, and slower tissue regeneration. Restoring NAD⁺ through supplementation has shown benefits in energy metabolism, neuroprotection, insulin sensitivity, and inflammatory regulation.

It is often used in anti-aging, performance, and detox protocols, or alongside fasting, exercise, and peptides like MOTS-c or Epitalon.

Scientific Background

NAD⁺ is a vital coenzyme found in every living cell, essential for cellular energy production, DNA repair, and healthy aging. It serves as a key player in redox reactions—the biochemical exchanges that generate ATP, the body’s energy currency. NAD⁺ also acts as a critical signaling molecule that regulates enzymes involved in longevity, inflammation control, metabolism, and stress resistance.Discovered over a century ago in yeast fermentation studies, NAD⁺ gained renewed scientific interest in recent decades due to its role in activating sirtuins—a family of proteins known for regulating aging and cellular resilience. As we age, NAD⁺ levels naturally decline, leading to mitochondrial dysfunction, increased oxidative stress, and a decreased ability to repair damaged DNA. This decline is now considered a hallmark of biological aging.

What makes NAD⁺ unique is its dual role: it’s not only essential for energy metabolism via glycolysis and oxidative phosphorylation, but it also functions as a substrate for enzymes like:

Sirtuins (SIRT1–SIRT7): Linked to enhanced lifespan, improved metabolic health, and anti-inflammatory effects.
PARPs (Poly ADP-ribose polymerases): Key for DNA repair and genomic stability.
CD38: An NAD-consuming enzyme involved in immune function and calcium signaling.

Replenishing NAD⁺ levels—either directly (through NAD⁺ injections) or indirectly (via precursors like NMN or NR)—has been shown in both animal and human studies to improve mitochondrial function, boost insulin sensitivity, enhance cognitive performance, and delay age-related decline.For example, a study by Gomes et al. (2013) demonstrated that restoring NAD⁺ levels in aged mice improved mitochondrial health and increased muscle function by activating SIRT1 and PGC-1α pathways [1]. In human trials, NAD⁺ infusion has been associated with increased energy, enhanced mental clarity, and improved metabolic markers [2].Today, NAD⁺ is at the forefront of longevity and regenerative medicine, used in protocols for anti-aging, detoxification, neuroprotection, and even addiction recovery, due to its ability to support neuroplasticity and stress resilience.

References

Gomes AP, Price NL, Ling AJY, et al. Declining NAD⁺ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624–1638. doi: 10.1016/j.cell.2013.11.037
Grant R, Nguyen S, McBean J. NAD⁺ therapy in patients with chronic fatigue: a pilot study. J Altern Complement Med. 2019;25(5):532–536. doi: 10.1089/acm.2019.0022
Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208–1213. doi: 10.1126/science.aac4854

Usage Instructions

Always refer to your product’s specific leaflet for full dosing and application instructions.

NAD⁺ may be available in various forms: injectable, nasal spray, or oral capsules. Store as directed — many forms require cool storage (2–8 °C) for stability.
For injections, use bacteriostatic water to reconstitute, swirl gently, and inject subcutaneously or intramuscularly depending on formulation.
For nasal spray, apply as directed, usually 1–2 sprays per nostril daily, preferably in the morning.

Dosage Information

Cognitive & Neurological Support:

Dose: 100–300 mg per day (oral/nasal), or 100–200 mg per injection
Supports focus, memory, and mental stamina

Anti-Aging & Mitochondrial Health:

Dose: 200–500 mg daily
Duration: Ongoing or in 8–12 week cycles
May be combined with MOTS-c, Resveratrol, NMN

Metabolic & Detox Support:

Dose: 300–600 mg during fasting, recovery, or detox phases
Frequency: Daily or alternate-day protocol for 2–4 weeks

Important Warnings

For research use only – not approved for clinical therapeutic use.
Store as instructed by formulation: vials or liquid forms usually at 2–8 °C, capsules in a cool, dry place.
Use bacteriostatic water for injectable reconstitution. Do not freeze unless specified.
Generally well tolerated; rare effects may include flushing, nausea, fatigue, or mild headache — often transient. Avoid use during pregnancy or active infection unless supervised.
Use sterile equipment and follow correct dosing. Stop use if symptoms persist or worsen.

Frequently Asked Questions

What Others Have Selected

35,00 €

35,00 €

40,00 €

60,00 €

45,00 €

40,00 €

40,00 €

45,00 €

90,00 €

40,00 €

40,00 €

45,00 €

Knowledge that might interest you

What Is Metabolic Flexibility — and Why Should You Care?

Unlock the Secret to Fat Loss, Better Energy, and Smarter Nutrition ## Why Some People Burn Fat Better Than Others You’ve probably seen it before — th...

Nervous System Fatigue: Why You Can’t Just ‘Push Through’ Forever

Most of us know the feeling of trying to do it all—pushing harder at the gym, staying later at work, or juggling more than feels sustainable. It’s eas...

What makes NAD⁺ unique is its dual role: it’s not only essential for energy metabolism via glycolysis and oxidative phosphorylation, but it also functions as a substrate for enzymes like:

Sirtuins (SIRT1–SIRT7): Linked to enhanced lifespan, improved metabolic health, and anti-inflammatory effects.
PARPs (Poly ADP-ribose polymerases): Key for DNA repair and genomic stability.
CD38: An NAD-consuming enzyme involved in immune function and calcium signaling.

Featured Categories

Browse All Categories

Featured Product

Featured Collections

Browse All Collections

Discover Lines

Featured Knowledge

Browse All Knowledge

Expert Knowledge

NAD+

Key Ingredients

Nicotinamide Adenine Dinucleotide (oxidized form)

Key BenefitsPlus IconMinus thin icon