SLU-PP-332 is an experimental compound developed to activate ERR (Estrogen-Related Receptor) pathways, particularly ERRα and ERRγ — two nuclear receptors that regulate mitochondrial gene expression and oxidative metabolism. These receptors are crucial for:
- Fatty acid oxidation (turning fat into usable energy)
- Glucose uptake and processing
- Mitochondrial biogenesis (creating more energy-producing organelles)
- Cardiovascular and skeletal muscle endurance
In preclinical studies, SLU-PP-332 has been shown to:
- Significantly increase expression of genes involved in mitochondrial energy production【1】
- Improve markers of exercise capacity and metabolic health in animal models【2】
- Enhance fat utilization without impacting food intake or relying on stimulants
The compound mimics some of the benefits of exercise at the molecular level, making it of interest for fat loss, endurance, metabolic syndrome, and age-related energy decline.While SLU-PP-332 is still under research, its mechanism offers a unique non-stimulant approach to metabolic enhancement that complements lifestyle protocols, fasting regimens, and peptide-based interventions.