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Hormonal Regulation

Peptides Line

Sermorelin

Name: Sermorelin
Brand: Peptalon
SKU: PE-0061-01-10
Availability: InStock
Rating: 4.8 (127 reviews)

Often used as a safer alternative to GH therapy, Sermorelin promotes hormonal balance, supports fat loss, sleep, recovery, and is popular in anti-aging protocols.

From $54.00

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Key Ingredients

Sermorelin Acetate

Balance Hormones

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Main Information

Sermorelin is a synthetic version of Growth Hormone Releasing Hormone (GHRH 1–29) — the first 29 amino acids of the full GHRH molecule, responsible for triggering growth hormone secretion. It stimulates the pituitary to release GH in a natural, regulated manner, supporting youthful hormone rhythms without suppressing the body’s feedback loop.

Sermorelin is widely used for anti-aging, fat metabolism, improved sleep, lean muscle support,and general recovery. It is well-tolerated, non-hormonal, and can be stacked with GHRPs like GHRP-2, GHRP-6, or Ipamorelin to maximize GH output.

Key Benefits

Stimulates natural GH release
Supports fat loss, sleep, tissue repair
Helps restore youthful hormone balance
Non-suppressive & HPTA friendly
Excellent alternative to synthetic GH therapy
Well-suited for long-term use

Scientific Background

Sermorelin is a synthetic peptide analogue of Growth Hormone–Releasing Hormone (GHRH 1–29), designed to stimulate the body’s natural production of human growth hormone (HGH) via the anterior pituitary gland. It represents the bioactive core of endogenous GHRH—the segment responsible for binding to GHRH receptors and initiating pulsatile GH release.Originally developed in the 1980s for the diagnosis and treatment of growth hormone deficiency (GHD), Sermorelin has since gained recognition for its application in anti-aging, recovery, and performance enhancement protocols.HSermorelin acts by stimulating the pituitary gland to secrete GH in a physiological, pulse-like manner, mimicking the body’s natural rhythms. This differs from exogenous HGH administration, which bypasses regulatory feedback and may suppress endogenous hormone production. By promoting endogenous GH release, Sermorelin indirectly increases IGF-1 (Insulin-Like Growth Factor 1) levels in the liver and peripheral tissues—enhancing anabolic repair, fat metabolism, cell regeneration, and neurological recovery.

Scientific Benefits & Applications

Body Composition: Sermorelin has been shown to support fat loss, particularly visceral adiposity, while preserving or increasing lean muscle mass .
Recovery & Tissue Repair: Through GH/IGF-1 pathways, it enhances collagen synthesis, joint recovery, and post-injury regeneration .

Sleep & Cognitive Function: Sermorelin may improve slow-wave (deep) sleep, which is closely linked to natural GH secretion, mental clarity, and emotional resilience.
Hormonal Balance: As it works upstream from GH, it preserves hypothalamic-pituitary axis (HPA) integrity—making it a more sustainable option than direct HGH therapy.

What Makes Sermorelin Unique

Stimulates the body’s own growth hormone in a pulsatile, physiologic way
Supports fat metabolism, muscle tone, and cellular repair
Preserves the natural endocrine feedback loop

Ideal for anti-aging, post-cycle recovery, and long-term regenerative strategies

References

Walker RF et al. Sermorelin: a diagnostic GH secretagogue in children and a potential therapy in adults. Endocrine. 1994;2(9):793–800. doi: 10.1007/BF02928554
Raiti S, Migeon CJ. A comparison of the growth hormone responses to insulin and to a synthetic polypeptide (Sermorelin). J Clin Endocrinol Metab. 1967;27(10):1506–1510. doi: 10.1210/jcem-27-10-1506
Van Cauter E, et al. Age-related changes in slow wave sleep and REM sleep and relationship with GH secretion. JAMA. 2000;284(7):861–868. doi: 10.1001/jama.284.7.861

Usage Instructions

Please refer to your product leaflet for detailed prep instructions.

Reconstitute the lyophilized powder with 1–2 ml bacteriostatic water.
Inject the liquid slowly into the vial and swirl gently until fully dissolved (do not shake).
Store the mixed solution in the refrigerator (2–8 °C) and use within 10–14 days.
Administer subcutaneously, preferably at night before bed or in the morning fasted.
To optimize GH release, avoid carbs or fats 1 hour before and after injection.
Can be used alone or stacked with GHRPs for enhanced effect.

Dosage Information

Anti-Aging / Wellness Protocol:

Dose: 200–300 mcg once daily
Timing: Pre-bed, fasted
Duration: 8–12 weeks, ongoing with breaks
May be stacked with Ipamorelin or GHRP-2

Recomposition / Recovery Protocol:

Dose: 200 mcg 2× daily (AM + PM)
Ideal during cutting, healing, or high-volume training
Stack with CJC-1295, GH boosters, or peptides like BPC-157

Beginner GH Support Protocol:

Dose: 100–200 mcg daily
Used for those looking to restore baseline GH rhythm gently

Important Warnings

For research use only – not approved for clinical GH replacement. Store unmixed vials refrigerated (2–8 °C).
Use bacteriostatic water only for reconstitution.
After mixing, use within 10–14 days.
Do not freeze.
Does not increase appetite or cortisol.
Safe for both men and women.
Use sterile syringes and rotate injection sites.
Mild side effects may include headache, flushing, or injection site sensitivity.

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Scientific Benefits & Applications

Body Composition: Sermorelin has been shown to support fat loss, particularly visceral adiposity, while preserving or increasing lean muscle mass .
Recovery & Tissue Repair: Through GH/IGF-1 pathways, it enhances collagen synthesis, joint recovery, and post-injury regeneration .

Sleep & Cognitive Function: Sermorelin may improve slow-wave (deep) sleep, which is closely linked to natural GH secretion, mental clarity, and emotional resilience.
Hormonal Balance: As it works upstream from GH, it preserves hypothalamic-pituitary axis (HPA) integrity—making it a more sustainable option than direct HGH therapy.

What Makes Sermorelin Unique

Stimulates the body’s own growth hormone in a pulsatile, physiologic way
Supports fat metabolism, muscle tone, and cellular repair
Preserves the natural endocrine feedback loop

Ideal for anti-aging, post-cycle recovery, and long-term regenerative strategies

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Sermorelin