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Key Ingredients
Alpha GPC
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Main Information
Alpha GPC is a highly bioavailable choline source that supports memory, learning, and neuroprotection by increasing acetylcholine levels in the brain. It’s a foundational nootropic for students, professionals, and anyone looking to enhance long-term cognitive function or performance.
Scientific Background
Alpha GPC (L-alpha glycerylphosphorylcholine) crosses the blood-brain barrier efficiently and delivers choline, the key precursor to acetylcholine, which governs learning, memory, and neural signaling.Studies show Alpha GPC increases acetylcholine synthesis, supports working memory, and may aid in neurogenesis — the formation of new brain cells【1】【2】. It’s also been shown to support physical performance, particularly power output and recovery, by influencing growth hormone release and muscle activation pathways【3】.It’s well-tolerated, even at higher doses, and stacks well with both stimulants and adaptogens.
References
Traini, E., Bramanti, V., & Amenta, F. (2013). “Choline alphoscerate (alpha-GPC): an old choline-containing phospholipid with a still interesting profile as cognition enhancing agent.” Current Alzheimer Research, 10(10), 1070–1079.
de Jesus Moreno Moreno, M. (2003). “Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate.” Methods and Findings in Experimental and Clinical Pharmacology, 25(7), 341–345.
Ziegenfuss, T. N., et al. (2008). “Effects of an acute oral dose of alpha-glycerylphosphorylcholine on growth hormone secretion and serum choline levels in healthy young males.” Journal of the International Society of Sports Nutrition, 5(1), 5.
Usage Instructions
- Take orally, with or without food.
- Best in the morning, or before tasks requiring concentration, memory, or mental clarity.
Dosage Information
- Cognitive support / daily brain health: 300–600 mg per day
- Pre-task boost or stacking: 600–1200 mg before performance
- Can be combined with caffeine, racetams, or adaptogens for synergistic effects
Important Warnings
- Well tolerated, but high doses may cause mild headaches (often resolved by co-supplementing with a choline modulator like L-theanine)
- Not recommended for individuals with cholinergic hypersensitivity
- Avoid combining with other choline sources in very high doses unless supervised
Key Ingredients
Alpha GPC
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application