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Key Ingredients
Methylthionine chlorid
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Main Information
Methylene Blue is a potent cognitive enhancer and cellular energizer that supports mitochondrial function, memory formation, and mood regulation. Originally developed as a medical dye, it has gained attention in neuroscience for its role in enhancing brain energy and protecting against oxidative stress.
Scientific Background
Methylene Blue (MB) has a long history in medicine — first synthesized in the 19th century and used as a dye, antiseptic, and even an early anti-malarial. In recent years, it has been rediscovered for its mitochondrial-boosting and nootropic properties.MB acts as an alternative electron carrier in the mitochondrial electron transport chain, meaning it can help the cell generate more ATP (energy) — even under stress or dysfunction【1】【2】. This makes it valuable for mental energy, neuroprotection, and brain repair.It also has antioxidant properties, reduces reactive oxygen species (ROS), and may improve memory encoding and retrieval by enhancing cellular metabolism in neurons【3】【4】. Low doses have even shown potential in preclinical studies for addressing depression-like symptoms, cognitive decline, and fatigue.However, MB is dose-sensitive — too much can have paradoxical or toxic effects, so precision and consistency are essential.
References
Gonzalez-Lima, F., & Barksdale, B. R. (2000). “The use of metabolic enhancers for memory improvement.” Current Opinion in Psychiatry, 13(2), 193–197.
Riha, P. D., Rojas, J. C., & Gonzalez-Lima, F. (2005). “Methylene Blue improves brain oxidative metabolism and memory retention in rats.” Pharmacology Biochemistry and Behavior, 77(1), 175–181.
Schindler, S. E., et al. (2016). “Neuroimaging of Methylene Blue in a Phase I Clinical Trial.” Neurotherapeutics, 13(3), 739–749.
Oz, M., et al. (2009). “Neuroprotective effects of methylene blue in Alzheimer’s disease.” Pharmacology & Therapeutics, 121(2), 127–140.
Usage Instructions
- This product is intended for oral use.
- Best taken in the morning or early afternoon, as it may increase alertness and energy. Avoid taking close to bedtime.
Dosage Information
- Standard cognitive support: 0.5–1 mg per kg body weight, once daily
- For fatigue or mental fog: up to 2 mg/kg body weight, taken with food
- Microdosing protocol: 0.5 mg/kg every other day, or 5 days on / 2 days off
- Do not exceed 2–3 mg/kg per day, and always ensure high-purity pharmaceutical-grade Methylene Blue is used
Important Warnings
- Do not combine with SSRIs, MAO inhibitors, or serotonergic medications — risk of serotonin syndrome
- Use with caution in individuals with G6PD deficiency
- Not recommended during pregnancy or breastfeeding
Key Ingredients
Methylthionine chlorid
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application