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Key Ingredients
Mesembryanthemum tortuosum
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Main Information
Kanna is a natural mood-brightening and stress-regulating botanical, traditionally used in South Africa for its calming and heart-opening effects. It supports emotional resilience, cognitive clarity, and a centered sense of well-being without sedation.
Scientific Background
Kanna (Sceletium tortuosum) contains active alkaloids like mesembrine, which act as selective serotonin reuptake inhibitors (SSRIs) and PDE4 inhibitors, influencing both mood and cognition.
Clinical studies have shown Kanna may help reduce anxiety, social withdrawal, and stress-induced cognitive dysfunction without impairing alertness【】.
Its ability to modulate serotonin reuptake and enhance the “serotonin cascade” may also make it valuable in mood stabilization protocols or as a gentle nootropic with emotional benefits.
References
Harvey BH, et al. “Effects of a standardized extract of Sceletium tortuosum (Zembrin®) on the brain’s threat circuitry.” J Ethnopharmacol. 2011.
Terburg D, et al. “The basolateral amygdala is critical for rapid escape: a human fMRI study.” Soc Cogn Affect Neurosci. 2013.
Usage Instructions
- This product is intended for oral use (capsule form).
- Take with or without food, ideally in moments of emotional strain, or as part of a morning routine for mood support.
Dosage Information
- For mood and anxiety support: 25–50 mg mesembrine alkaloid equivalents once daily
- For social and stress resilience: taken 30–60 minutes before an anticipated event
- Cycling use is recommended after 6–8 weeks of daily use to preserve receptor sensitivity
Important Warnings
- Do not combine with SSRIs, MAOIs, or serotonergic medications unless under medical supervision
- May cause mild euphoria or emotional openness; avoid operating heavy machinery until familiar with effects
- Not recommended during pregnancy or breastfeeding
Key Ingredients
Mesembryanthemum tortuosum
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application