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Dermorphin

Name: Dermorphin
Brand: Peptalon
SKU: PE-0267-01-5
Availability: InStock
Rating: 4.8 (127 reviews)

Demorphin is a powerful, naturally derived opioid peptide known for its potent pain-relieving) effects with high selectivity for mu-opioid receptors—offering intense relief at microdoses.

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Demorphin

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Main Information

Demorphin is a naturally occurring opioid peptide known for its exceptional potency as a selective mu-opioid receptor agonist. Originally isolated from the skin of South American frogs, it delivers intense pain relief at microgram-level doses, often outperforming morphine while showing a lower risk of tolerance, sedation, or respiratory depression in research settings.As a neuroactive peptide, Demorphin is under study for its potential use in advanced pain management, central nervous system modulation, and post-injury recovery. Its targeted mechanism makes it a unique tool in high-intensity relief protocols where conventional painkillers may be insufficient.

Scientific Background

Demorphin is a small peptide originally discovered in the skin of South American Phyllomedusa frogs. What makes it unique is its incredibly strong effect on the body’s natural opioid system — it binds very specifically to μ-opioid receptors (the same targets as morphine), but it does so much more potently and precisely.

Early research showed that Demorphin could produce powerful pain-relieving effects at microgram-level doses — meaning up to 30 to 1000 times stronger than morphine, but requiring much less substance to work.

This was first described in a study by Erspamer and colleagues in 1981, who also noted its high receptor selectivity, meaning it mostly interacts with the exact target intended, reducing “off-target” effects (Erspamer et al., 1981).Further studies explored how Demorphin behaves in the body.

Compared to traditional opioids, it appeared to cause less respiratory depression at effective doses and develop tolerance more slowly, at least in animal models (Richards & Sadee, 1985; Riviere et al., 1988). This has made it an interesting compound for scientists studying new ways to manage pain or understand how the opioid system works without the usual side effects seen with strong painkillers.Because of its strength and precise action, Demorphin is used strictly for research purposes, especially in pain, neurobiology, and receptor response studies.

References

Erspamer V. et al. Proc Natl Acad Sci USA. 1981;78(9):5520–5523. PMID: [6273893]
Richards ML, Sadee W. J Pharmacol Exp Ther. 1985;233(1):1–7. PMID: [3927439]
Riviere PJ et al. Eur J Pharmacol. 1988;151(3):399–406. PMID: [2906900]

Usage Instructions

Best Practices:

Always use new sterile syringes
Rotate injection sites to prevent irritation
Avoid combining with sedatives, depressants, or alcohol
Monitor for signs of CNS overstimulation or discomfort
Not intended for unsupervised or recreational use
Form: Subcutaneous injection
Timing: Once daily or as needed depending on research protocol
Cycle Length: 3–7 days per cycle, followed by washout phase

Dosage Information

Research dosage range:

2–10 µg per dose, administered 1x per day, depending on sensitivity and intended effect.

Potency is extremely high — start at the lowest effective dose (e.g., 2 µg).

Duration of cycle: 5 to 7 days, or as part of short-term pain management or neuromodulation protocol.

Do not exceed 10 µg per day without clinical oversight.

Important Warnings

Extremely potent μ-opioid receptor agonist — significantly more active than morphine.
May cause sedation, respiratory depression, bradycardia, or euphoria, especially in opioid-naive individuals.
Not for use in combination with other CNS depressants (e.g., alcohol, benzodiazepines, opioids).
Avoid operating machinery or driving post-administration.
Not suitable for individuals with respiratory disorders, severe liver/kidney dysfunction, or opioid sensitivity.
Keep out of reach of children and pets.
Research-only compound — not approved for human use outside experimental settings.

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Dermorphin