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HGH Fragment 176-191
HGH Fragment 176–191 is a synthetic peptide derived from the fat-burning region of human growth hormone (amino acids 176 to 191). It selectively targets adipose (fat) tissue, promoting lipolysis and inhibiting lipogenesis, without affecting blood sugar or cell growth. Ideal for users focused on fat loss, body recomposition, or metabolic optimization, without the broader effects of full-length HGH.
Key Ingredients
Synthetic peptide corresponding to amino acids 176 to 191 of human growth hormone (somatotropin).
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
Main Information
HGH Fragment 176-191 is a specialized peptide derived from the fat-burning region of the human growth hormone molecule. Designed to stimulate lipolysis without the unwanted effects on blood sugar or IGF-1 levels, this fragment supports targeted fat reduction—especially around the abdomen—without promoting muscle growth or organ enlargement. Its short half-life makes it ideal for fasted morning use or post-workout applications, helping users in cutting phases or metabolic protocols optimize fat loss. HGH Frag is widely used for body recomposition, anti-obesity strategies, and aesthetic enhancement with a high safety margin.
Scientific Background
HGH Fragment 176–191, often called HGH Frag, is a specialized peptide derived from the human growth hormone (HGH) molecule. Unlike full-length HGH, which influences many systems in the body, HGH Frag is a short segment of just 15 amino acids — specifically the region believed to control fat metabolism. Scientists first identified this fragment when studying the structure of HGH in the late 1970s and 1980s, discovering that this particular sequence was responsible for its lipolytic (fat-burning) effects, without the unwanted side effects of full HGH therapy.
What makes HGH Frag unique is that it does not affect growth or blood sugar regulation in the way traditional HGH does. Instead, it works almost exclusively on adipose tissue, stimulating the breakdown of fat cells (lipolysis) and preventing the creation of new fat deposits (lipogenesis). Research shows it is especially effective on stubborn fat areas such as the abdomen, hips, and thighs, where many people struggle to lose weight despite diet and exercise.
Unlike traditional fat burners that rely on stimulants, HGH Frag works by enhancing the body’s natural metabolic processes, meaning it can support steady, sustainable fat reduction without causing jitters, insomnia, or overstimulation of the nervous system. Its selective action makes it a promising tool in both medical weight management and modern wellness protocols focused on body composition, longevity, and metabolic health.
References
Heffernan M, et al. GH fragment 177–191 enhances lipolysis and inhibits lipogenesis in adipose tissue in vitro. J Endocrinol. 2000;166(1):11–20. doi:10.1677/joe.0.1660011
Usage Instructions
Instructions for Use
- To ensure safe and effective use of HGH Fragment 176–191, it’s important to follow correct preparation, handling, and injection techniques. Below is a summary of the most essential steps. For detailed guidance, please refer to the official Product Leaflet included with your vial.
- Inspect the solution before each use by gently tipping or swirling the vial or preloaded syringe once or twice.
- Do not use if the solution appears cloudy, discolored, or contains particles.
Reconstitution:
- HGH Fragment 176–191 is typically supplied as a lyophilized (freeze-dried) powder. Reconstitute using bacteriostatic water.
- Inject slowly along the vial wall and swirl gently (do not shake) until fully dissolved and clear.
Injection format:
- This peptide is intended for subcutaneous injection using insulin syringes (up to 16 mm needle length).
- Always use a new, sterile syringe and needle for every injection.
- Maintain aseptic technique and never reuse syringes.
Storage and handling:
- Store the lyophilized powder refrigerated at 2–8 °C.
- After reconstitution, use within 7–14 days, keeping the solution refrigerated.
- Do not freeze. Protect from light.
Do not share your HGH Fragment 176–191 vial or syringes with anyone else – even if sterile equipment is used – to prevent contamination and health risks.
Dosage Information
HGH Fragment 176-191 is typically administered via subcutaneous injection, often around the abdominal area to target stubborn fat deposits.
Suggested dosage:
- 250–500 mcg per injection
- 1–2 times daily, ideally:
- First dose in the morning, fasted
- Second dose post-workout or before bed for enhanced fat mobilization
Cycle duration:
- Commonly used in 4–8 week cycles
- Best results seen when combined with a calorie-controlled diet and light cardio or training routine
Due to its short half-life (~30 minutes), split dosing or timing around metabolic activity peaks (e.g. morning or post-exercise) enhances its fat-burning effects.
Important Warnings
Warnings and Precautions
- For research use only: Not approved for medical treatment or human consumption in many countries.
- Avoid use in children or during pregnancy/breastfeeding: No safety data exists.
- Do not exceed recommended dosage: Higher doses do not necessarily increase fat loss and may lead to peptide tolerance or desensitization.
- Injection site rotation is advised to avoid local irritation or tissue sensitivity.
- Hypoglycemia risk is low, but monitor blood sugar if combined with other metabolic agents or during fasting protocols.
- Storage: Keep reconstituted solution refrigerated (2–8°C) and use within the manufacturer’s recommended timeframe.
- Always consult a qualified health professional before starting peptide-based protocols—especially if you have underlying health conditions or are taking medications.
HGH Fragment 176-191
HGH Fragment 176–191 is a synthetic peptide derived from the fat-burning region of human growth hormone (amino acids 176 to 191). It selectively targets adipose (fat) tissue, promoting lipolysis and inhibiting lipogenesis, without affecting blood sugar or cell growth. Ideal for users focused on fat loss, body recomposition, or metabolic optimization, without the broader effects of full-length HGH.
Key Ingredients
Synthetic peptide corresponding to amino acids 176 to 191 of human growth hormone (somatotropin).
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application