Epitalon (also known as Epithalamin or Ala-Glu-Asp-Gly) is a synthetic tetrapeptide that mimics a naturally occurring compound secreted by the pineal gland. It was originally developed by Russian scientist Prof. Vladimir Khavinson as part of anti-aging and geroprotection research conducted at the St. Petersburg Institute of Bioregulation and Gerontology.Epitalon gained scientific attention for its ability to regulate melatonin secretion, modulate gene expression, and influence telomerase activity — an enzyme responsible for maintaining the length of telomeres, which protect DNA during cell division. Shortened telomeres are considered one of the hallmarks of aging.

In a landmark animal study, Epitalon administration led to increased telomerase activity, lengthened telomeres, and extended lifespan in mice (Khavinson et al., 2003). Further research in aged monkeys and rats demonstrated improvements in immune function, circadian rhythm regulation, and stress resilience (Anisimov et al., 2001).One of Epitalon’s most cited benefits is its normalization of melatonin production, which often declines with age. Human studies in elderly subjects showed that Epitalon could restore youthful sleep-wake cycles and increase nighttime melatonin levels without causing dependence or hormonal suppression (Khavinson et al., 2002).While Epitalon remains a research compound in most countries, its low toxicity and favorable safety profile have made it a subject of ongoing clinical and anti-aging interest.

In summary, research suggests that Epitalon may support:

• Telomere maintenance and genomic stability

• Improved sleep quality via natural melatonin regulation

• Immune system modulation and oxidative stress reduction

• Potential lifespan extension and delayed onset of age-related decline