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Lipotropin

Lipotropin (β-Lipotropin) is a naturally occurring peptide hormone derived from the POMC precursor in the pituitary gland. Known for its ability to stimulate lipolysis, Lipotropin helps the body break down and mobilize stored fat for energy. It also acts as a precursor to important molecules like β-endorphin and melanocyte-stimulating hormones (MSH), which may contribute to mood, pigmentation, and metabolic function. Ideal for advanced users seeking fat loss support with neurohormonal benefits.

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Key Ingredients

β-Lipotropin

Visceral Fat Reduction

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Main Information

Lipotropin is a peptide hormone originally derived from pro-opiomelanocortin (POMC), developed for its ability to promote fat mobilization and metabolic stimulation. It works by triggering the breakdown of stored fat (lipolysis), helping the body use fat as energy more efficiently. Often used in cutting protocols or metabolic stacks, Lipotropin supports body recomposition, energy regulation, and fat loss, especially when combined with exercise and a balanced diet. Its natural origin and compatibility with the body’s own endocrine processes make it a valuable tool for optimizing fat metabolism in a controlled and targeted way.

Scientific Background

Lipotropin was first isolated in the 1960s during research on pituitary hormones, specifically from the larger precursor molecule pro-opiomelanocortin (POMC). This precursor also gives rise to other key hormones such as ACTH and MSH peptides. Lipotropin itself comes in two forms: β-lipotropin and γ-lipotropin, with β-lipotropin being the more studied variant for fat metabolism and endorphin-related functions. The key role of Lipotropin lies in its lipolytic activity—it promotes the release of fatty acids from adipose tissue by enhancing the activity of hormone-sensitive lipase. This process allows the body to convert stored fat into usable energy, particularly under caloric restriction or physical exertion.

Additionally, β-lipotropin contains sequences that resemble endorphins, giving it potential neuromodulatory effects such as mood support, appetite regulation, and increased energy perception. Some studies also suggest that it may help regulate cholesterol transport and support liver fat metabolism, making it relevant in metabolic health strategies.

Lipotropin is often considered a more natural, endocrine-compatible fat-loss aid, especially when used in conjunction with peptides like HGH Fragment 176-191, CJC-1295, or Carnitine for enhanced results.

References

Li CH, Chung D. β-Lipotropin—Structure and Lipolytic Activity. Proc Natl Acad Sci USA. 1976;73(10):3162–3164. doi:10.1073/pnas.73.10.3162
O’Donohue TL, Dorsa DM, Mezey E, et al. Beta-Lipotropin and related peptides: localization in rat brain and pituitary. Brain Res. 1979;170(1):149–157. doi:10.1016/0006-8993(79)90946-5
Ronsin G, et al. Lipotropic agents: action on hepatic cholesterol metabolism. Biochem Pharmacol. 1982;31(8):1331–1335. doi:10.1016/0006-2952(82)90037-2

Usage Instructions

To ensure safe and effective use of Peptide Products, like Lipotropin, it’s important to follow correct preparation, handling, and injection techniques. Below is a summary of the most essential steps. For detailed guidance, please refer to the official Product Leaflet included with your vial. You can also view the the Leaflet online at the right bottom of the product page.

Inspect the solution before each use by gently tipping or swirling the vial or preloaded syringe once or twice.
Do not use if the solution appears cloudy, discolored, or contains particles.
Peptide products are typically supplied as a lyophilized (freeze-dried) powder.
Reconstitute using bacteriostatic water.
Inject slowly along the vial wall and swirl gently (do not shake) until fully dissolved and clear.
This peptide is intended for subcutaneous injection using insulin syringes (up to 16 mm needle length).
Always use a new, sterile syringe and needle for every injection.
Maintain aseptic technique and never reuse syringes.
Rotate the injection sites (e.g., abdomen, thighs, or upper arm) to avoid local irritation or tissue damage.
Before injecting, check that the syringe is correctly loaded: a small drop of solution should appear at the needle tip. If not, discard the syringe and prepare a new one.
Refer to sections E–G on pages 10–11 of the Product Leaflet for visual instruction, if available.
Store the lyophilized powder refrigerated at 2–8 °C.
After reconstitution, use within 7–14 days, keeping the solution refrigerated.
Do not freeze. Protect from light.

Dosage Information

The recommended dosage of Lipotropin depends on the user’s goal, experience level, and whether it is used alone or as part of a fat loss stack. Lipotropin is typically administered via subcutaneous injection, once or twice daily.

General Fat Loss & Body Recomposition:

For individuals aiming to support gradual, sustainable fat loss:

Dosage: 200–300 mcg per day
Timing: Once daily in the morning or pre-workout
Cycle Length: 6–8 weeks, followed by a 2–4 week break

Accelerated Cutting Phase (Advanced Users):

For experienced users during a defined cutting period:

Dosage: 300–500 mcg daily, divided into two doses
Timing: Morning (fasted) and post-workout or before bed

• Cycle Length: Up to 8 weeks; not recommended beyond 12 weeks without medical supervision

3. Stack Use with Other Fat-Burning Peptides (e.g., HGH Fragment 176-191, CJC-1295, or Yohimbine):

• Reduce Lipotropin dosage to 200–250 mcg daily to avoid overstimulation

• Monitor cardiovascular and metabolic markers more frequently

• Coordinate dosing with other compounds to avoid overlap in stress on liver or endocrine function

4. Female-Friendly Protocol:

Due to its relatively gentle profile, Lipotropin is considered suitable for women:

• Dosage: 100–250 mcg daily

• Cycle: 4–6 weeks

• Start with the lowest effective dose and monitor response

Important Warnings

To ensure both the effectiveness and safety of a Lipotropin cycle, the following health markers should be checked regularly:

Body fat percentage -Track weekly using a reliable body composition scale to evaluate fat loss progress.
Blood glucose levels -Measure every 2 weeks to detect any impact on glucose metabolism.
Liver function (ALT, AST, GGT) -Check via blood panel after 4–6 weeks to monitor liver stress or toxicity.
Kidney function (Creatinine, eGFR)-Test every 4 weeks to ensure healthy breakdown and excretion of peptide metabolites.
Blood pressure & heart rate Monitor regularly at home, as fat-mobilizing agents can affect cardiovascular parameters.

Other Important Notes on Safe Use

Stay hydrated- Aim for 2.5 to 3.5 liters of water per day, as fat breakdown can increase fluid loss.
Adjust your diet -A calorie-reduced, protein-rich nutrition plan boosts Lipotropin’s effectiveness and supports muscle retention.
Exercise regularly - Combine aerobic training (e.g., cardio, HIIT) with strength workouts to maximize fat loss and improve body composition.
Remember the fundamentals -Lipotropin is a metabolic enhancer—not a replacement for healthy habits. Sustainable results depend on consistency in lifestyle, nutrition, and activity.