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CJC 1295
CJC-1295 without DAC is a fast-acting Growth Hormone Releasing Hormone (GHRH) analog that stimulates natural GH secretion in short, controlled pulses
Key Ingredients
CJC-1295 without Drug Affinity Complex
Boosts Recovery
Fat Burning Support
Growth Hormone Optimization
Supports Healthy Aging
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
Main Information
CJC-1295 (without DAC) is a synthetic GHRH analog that stimulates the pituitary gland to release growth hormone (GH) in natural, pulsatile bursts. Unlike the DAC version (which provides a constant release), the no DAC form mimics natural GH rhythms, making it ideal for stacking with GHRP peptides for synergistic effects.Used in anti-aging, fat-loss, and recovery-focused protocols, CJC-1295 helps boost GH production without suppressing the body’s natural balance. When combined with GHRP-2, GHRP-6, or Ipamorelin, it amplifies growth hormone output and supports cell repair, deep sleep, metabolism, and tissue regeneration.
Key Benefits
- Increases natural GH secretion in pulses
- Enhances muscle repair, recovery, and fat loss
- Supports deeper sleep and collagen synthesis
- Best when stacked with GHRPs
- Non-hormonal and well-tolerated
Scientific Background
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH), designed to stimulate the pituitary gland to increase natural secretion of growth hormone (GH). Unlike native GHRH, CJC-1295 has been modified with a Drug Affinity Complex (DAC), which extends its half-life significantly—from minutes to more than 7 days—allowing for weekly rather than multiple daily injections.This extended activity makes CJC-1295 particularly valuable in protocols targeting fat loss, muscle growth, improved sleep, and anti-aging benefits, as it mimics the pulsatile GH release pattern, rather than overwhelming the system with exogenous GH.
What the Science Says: Summary of Key Studies
Long-Acting GH-Releasing Hormone Analogue in Humans
In a landmark clinical study by Teichman et al., healthy volunteers received subcutaneous injections of CJC-1295. The results showed:
- A two- to ten-fold increase in mean GH levels for up to 6 days after a single injection.
- A significant elevation of IGF-1 (Insulin-like Growth Factor 1) that lasted for up to 10 days.
- No evidence of desensitization or pituitary suppression, even with repeated dosing.
Mechanism Behind the Long Half-Life - CJC-1295’s extended half-life is made possible by covalent binding to albumin, which protects it from enzymatic degradation and rapid renal clearance. This mechanism avoids frequent spikes and mimics a more physiological GH profile.
Synergy with GHRP-6 or Ipamorelin - Several animal and clinical studies suggest that combining CJC-1295 with growth hormone secretagogues (GHS) like GHRP-6 or Ipamorelin enhances the pulsatile GH release through dual receptor activation—one targeting the GHRH receptor, the other targeting the ghrelin receptor. This mimics natural GH pulses, with lower risk of desensitization.
By enhancing natural hormone function, CJC-1295 offers a regulated and more physiological path to performance and wellness—supported by both pharmacokinetics and clinical outcomes.
References
Reference: Teichman SL et al. (2006). Pharmacokinetics and pharmacodynamics of CJC-1295, a long-acting growth hormone releasing hormone analog, in healthy adults. J Clin Endocrinol Metab, 91(3):799-805. doi:10.1210/jc.2005-1536
Supported by: Frohman LA, et al. (2001). Novel peptidomimetics and analogs of GHRH. Endocr Rev, 22(6):768–780. doi:10.1210/er.22.6.768
Chen HY, et al. (2009). Ghrelin receptor agonists synergize with GHRH analogs. Peptides, 30(6):1026–1033. doi:10.1016/j.peptides.2009.01.018
Usage Instructions
Refer to the leaflet included with your product for detailed handling.
- Reconstitute the lyophilized peptide with 1–2 ml bacteriostatic water, injecting slowly into the vial and swirling gently (do not shake).
- Store reconstituted solution in the refrigerator (2–8 °C) and use within 10–14 days.
- Administer via subcutaneous injection, preferably 30–60 minutes before bed or after training.
- For best results, use on an empty stomach, and avoid carbs or fats around injection time to prevent GH blunting.
Dosage Information
Basic GH Optimization Protocol:
- Dose: 100 mcg once or twice daily
- Timing: Pre-bed or morning fasted
- Use with: GHRP-2, GHRP-6, or Ipamorelin for max synergy
Performance or Recomposition Cycle:
- Dose: 100 mcg 2–3× daily
- Cycle Duration: 8–12 weeks
- Stack with: IGF-1 LR3, GH mimetics, or fat-burning peptides
Anti-Aging Protocol:
- Dose: 100 mcg once daily, pre-bed
- Duration: Ongoing or in 8-week cycles
Important Warnings
- For research use only – not approved for human therapeutic use
- Store unreconstituted vials refrigerated (2–8 °C)
- Use only bacteriostatic water to mix
- After reconstitution, keep refrigerated and use within 10–14 days
- Do not freezeUse sterile insulin syringes and rotate injection sites
- Avoid use during illness or if experiencing abnormal pituitary symptoms
- Discontinue if unexpected water retention, fatigue, or headaches occur
CJC 1295
CJC-1295 without DAC is a fast-acting Growth Hormone Releasing Hormone (GHRH) analog that stimulates natural GH secretion in short, controlled pulses
Key Ingredients
CJC-1295 without Drug Affinity Complex
Boosts Recovery
Fat Burning Support
Growth Hormone Optimization
Supports Healthy Aging
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
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