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Key Ingredients
Larazotide acetate
Safe For Prolongued Use
Safe and Natural
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
Main Information
Larazotide Acetate is a tight junction regulator peptide originally developed for the treatment of leaky gut and gluten-related disorders. By modulating intestinal permeability, Larazotide helps reduce inflammation, protect gut lining integrity, and support a balanced immune response - making it a promising tool for anyone dealing with gut-driven issues, food sensitivities, or systemic inflammation.
Scientific Background
Larazotide Acetate (also known as AT-1001) is a synthetic octapeptide that acts on the tight junctions between intestinal cells. These tight junctions regulate what enters the bloodstream from the gut. When disrupted — as in cases of leaky gut or celiac disease — toxins, undigested food particles, and pathogens can pass through and trigger systemic inflammation.Larazotide works by inhibiting zonulin, a protein that loosens tight junctions in response to stress, gluten, or infection. By stabilizing the gut barrier, it reduces the translocation of inflammatory triggers and lowers systemic immune activation.It has been tested in phase II clinical trials for celiac disease, where it was shown to reduce gluten-induced symptoms and improve intestinal integrity without suppressing the immune system.
This makes Larazotide a unique option for:
- Managing gut permeability
- Supporting autoimmune conditions
- Improving tolerance to food antigens
- Reducing neuroinflammation and skin flare-ups tied to gut dysfunction
References
Leffler, D. A. et al. (2015). “A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge.” Alimentary Pharmacology & Therapeutics, 42(2), 273–285.
Fasano, A. (2012). “Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.” Physiological Reviews, 91(1), 151–175.
Usage Instructions
- This product is typically taken orally in capsule form, ideally on an empty stomach or 30 minutes before meals.
- Take with a full glass of water.
- Consistency is key for cumulative effects, especially when used for gut support or immune modulation.
Dosage Information
Celiac or gluten sensitivity support:
- 0.5–1 mg before meals containing gluten or potential irritants
Leaky gut / IBS / skin flare-up modulation:
- 1–2 mg daily, taken in 2 divided doses (AM and PM)
Systemic inflammation / autoimmune support:
- Up to 3 mg daily, ideally under practitioner guidance
Important Warnings
- Do not use if you have a known hypersensitivity to peptides.
- Avoid during pregnancy or breastfeeding unless advised by a medical professional.
- Store in a cool, dry place away from heat and direct sunlight.
- For gastrointestinal support purposes only; not intended to replace gluten-free diets in celiac patients unless supervised.
Key Ingredients
Larazotide acetate
Safe For Prolongued Use
Safe and Natural
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
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