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Health & Longevity

Peptides Line

MOTS-C

Name: MOTS-C
Brand: Peptalon
SKU: PE-0023-01-2
Availability: InStock
Rating: 4.8 (127 reviews)

MOTS-c is a mitochondria-derived peptide that regulates metabolism, insulin sensitivity, and cellular energy. It acts as a potent AMPK activator, mimicking the effects of exercise and promoting fat loss, glucose control, and resilience against stress and aging.

From AED 230.00

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Key Ingredients

MOTS-c acetate

Safe and Natural

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA (mtDNA) — a rare feature that gives it direct influence over cellular energy balance and metabolic stress response. It activates AMPK, a cellular energy sensor, and enhances the expression of genes involved in:

Fat oxidation
Insulin sensitivity
Glucose uptake
Mitochondrial biogenesis
Cellular stress adaptation

In preclinical studies, MOTS-c improved body composition, endurance, cognitive resilience, and lifespan, especially under metabolic or age-related stress.

Scientific Background

MOTS-c (short for Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a groundbreaking peptide that belongs to a new class of molecules known as mitochondrial-derived peptides (MDPs). Unlike most peptides that are encoded in the cell nucleus, MOTS-c is encoded within the mitochondrial genome—a rare and significant distinction. This peptide plays a vital role in cellular metabolism, stress response, and energy regulation, positioning it at the frontier of both longevity research and metabolic optimization.MOTS-c was first identified in 2015 by researchers at the University of Southern California, including Dr. Pinchas Cohen, during studies investigating non-nuclear genetic contributions to aging and disease resistance .

The discovery was revolutionary: it demonstrated that mitochondria can produce bioactive signaling peptides that regulate nuclear gene expression—essentially acting as messengers between mitochondria and the rest of the cell.One of the most important mechanisms of MOTS-c is its ability to activate AMPK (AMP-activated protein kinase), a key energy-sensing enzyme that promotes fatty acid oxidation, glucose uptake, and mitochondrial biogenesis. This makes MOTS-c functionally similar to exercise at the cellular level—earning it the nickname “exercise mimetic.” When energy levels are low (as in fasting or physical exertion), MOTS-c helps shift the cell’s metabolism toward greater energy efficiency, while also improving insulin sensitivity and glucose regulation. In animal models, MOTS-c has demonstrated impressive protective and performance-enhancing effects. One pivotal study showed that mice treated with MOTS-c had improved exercise capacity, greater resistance to diet-induced obesity, and enhanced insulin responsiveness . Another study showed that MOTS-c can protect cells from oxidative stress and delay the onset of age-related insulin resistance, supporting its potential role in healthy aging .

What makes MOTS-c particularly unique is:

Its mitochondrial origin, offering a new biological pathway for metabolic intervention.
Its broad spectrum of benefits, ranging from fat loss and metabolic balance to anti-inflammatory and longevity-enhancing properties.
Its non-hormonal and well-tolerated profile, making it attractive for long-term use in aging and performance optimization.

In practical application, MOTS-c is being explored not just for fat metabolism and energy enhancement, but also as a therapeutic candidate for metabolic syndrome, type 2 diabetes, and age-related functional decline—with early results showing strong promise.

References

Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454. doi: 10.1016/j.cmet.2015.02.009
Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470. doi: 10.1038/s41467-020-20652-3
Lu H, Zhang L, Liu N, et al. MOTS-c peptide regulates adipose homeostasis to combat diet-induced obesity. Aging (Albany NY). 2019;11(12):5330–5341. doi: 10.18632/aging.102119

Usage Instructions

To ensure safe and effective use of Peptide Products, like MOTS-C, it’s important to follow correct preparation, handling, and injection techniques. Below is a summary of the most essential steps. For detailed guidance, please refer to the official Product Leaflet included with your vial. You can also view the the Leaflet online at the right bottom of the product page.

Inspect the solution before each use by gently tipping or swirling the vial or preloaded syringe once or twice.
Do not use if the solution appears cloudy, discolored, or contains particles.
Peptide products are typically supplied as a lyophilized (freeze-dried) powder.
Reconstitute using bacteriostatic water.
Inject slowly along the vial wall and swirl gently (do not shake) until fully dissolved and clear.
This peptide is intended for subcutaneous injection using insulin syringes (up to 16 mm needle length).
Always use a new, sterile syringe and needle for every injection.
Maintain aseptic technique and never reuse syringes.
Rotate the injection sites (e.g., abdomen, thighs, or upper arm) to avoid local irritation or tissue damage.
Before injecting, check that the syringe is correctly loaded: a small drop of solution should appear at the needle tip. If not, discard the syringe and prepare a new one.
Refer to sections E–G on pages 10–11 of the Product Leaflet for visual instruction, if available.
Store the lyophilized powder refrigerated at 2–8 °C.
After reconstitution, use within 7–14 days, keeping the solution refrigerated.
Do not freeze. Protect from light.

Dosage Information

Metabolic Optimization / Fat Loss Protocol:

Dose: 10–20 mg per injection
Frequency: 3× per week or daily (on training days) ,Best taken AM or pre-workout

Insulin Sensitivity / Glucose Control Support:

Dose: 10 mg per day
Use before meals or in fasted state, Can be stacked with Berberine, ALA, NAD+

Longevity & Mitochondrial Support:

Dose: 5–15 mg, 2–3× per week
Cycle: 4–6 weeks on, followed by short break
Stack with Epitalon, NAD+, or GH secretagogues

Important Warnings

For research and advanced wellness use only
Store unmixed vial at 2–8 °C
Once reconstituted, use within 7–10 days
Do not freeze
Side effects are rare but may include mild fatigue, muscle tightness, or headache during adaptation phase
May lower blood glucose slightly — monitor if on anti-diabetic medications
Not recommended for use during pregnancy or active illness

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What makes MOTS-c particularly unique is:

Its mitochondrial origin, offering a new biological pathway for metabolic intervention.
Its broad spectrum of benefits, ranging from fat loss and metabolic balance to anti-inflammatory and longevity-enhancing properties.
Its non-hormonal and well-tolerated profile, making it attractive for long-term use in aging and performance optimization.

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