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Triptorelin
Triptorelin is a potent GnRH agonist peptide used to suppress or reset hormonal function by temporarily desensitizing the pituitary gland.
Key Ingredients
Triptorelin Acetate
Regulates Reproductive Health
Hormone Regulation
Boosts LH and FS release
Female Friendly
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
Main Information
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) agonist, structurally similar to endogenous GnRH but modified for increased potency and longer duration. It works by initially stimulating the pituitary to release LH and FSH, followed by desensitization of GnRH receptors, leading to a temporary hormonal shutdown (downregulation).Clinically used to treat prostate cancer, endometriosis, and precocious puberty, Triptorelin is also explored in the performance and recovery context for:
- HPTA restart therapy
- Hormonal reset after anabolic cycles
- Testosterone suppression during TRT pause or fertility protocols
Scientific Background
Triptorelin is a long-acting synthetic analogue of gonadotropin-releasing hormone (GnRH), developed in the late 1970s as part of therapeutic strategies to control sex hormone–dependent conditions. It acts by mimicking endogenous GnRH at the pituitary level, but with enhanced receptor affinity and resistance to enzymatic degradation.Upon administration, Triptorelin induces a transient surge in LH and FSH—known as the “flare” effect—followed by receptor desensitization and a sustained suppression of gonadotropin output. This results in a reversible decrease in testosterone or estradiol to near-castration levels, making it highly effective for androgen-sensitive cancers, endometriosis, and assisted reproductive protocols.
In sports endocrinology and post-cycle therapy (PCT), Triptorelin is valued for its ability to reboot the hypothalamic-pituitary-gonadal (HPG) axis, especially after anabolic steroid use. At lower doses, it can stimulate LH/FSH release transiently to accelerate testicular function recovery without long-term suppression .Ideal for use in hormonal reset protocols, fertility recovery, or short-term suppression of sex hormones under clinical guidance.
What Makes Triptorelin Unique
- Unlike hCG or Clomiphene, Triptorelin targets the central regulatory axis (hypothalamus–pituitary), not just the testes
- Offers both short-term stimulation and long-term suppression depending on dose and duration
- Used clinically in both male and female hormonal protocols, with well-documented safety and efficacy
- Especially effective in single-dose PCT protocols, where fast HPG reboot is needed post-anabolic cycles
- Long history of use in oncology and reproductive medicine, with precise hormonal control
Ideal for targeted hormone suppression, fertility recovery, or post-cycle endocrine stabilization.
References
Tolis G et al. Endocrine effects of long-term administration of D-Trp6-LHRH in men. J Clin Endocrinol Metab. 1982;54(1):147–152. doi: 10.1210/jcem-54-1-147
Crawford ED. Hormonal therapy in prostate cancer: historical approaches. Rev Urol. 2004;6(Suppl 7):S3–S11. PMID: 16985889
Usage Instructions
To ensure safe and effective use of Peptide Products, like Triptorelin, it’s important to follow correct preparation, handling, and injection techniques. Below is a summary of the most essential steps. For detailed guidance, please refer to the official Product Leaflet included with your vial. You can also view the the Leaflet online at the right bottom of the product page.
- Inspect the solution before each use by gently tipping or swirling the vial or preloaded syringe once or twice.
- Do not use if the solution appears cloudy, discolored, or contains particles.
- Peptide products are typically supplied as a lyophilized (freeze-dried) powder.
- Reconstitute using bacteriostatic water.
- Inject slowly along the vial wall and swirl gently (do not shake) until fully dissolved and clear.
- This peptide is intended for subcutaneous injection using insulin syringes (up to 16 mm needle length).
- Always use a new, sterile syringe and needle for every injection.
- Maintain aseptic technique and never reuse syringes.
- Rotate the injection sites (e.g., abdomen, thighs, or upper arm) to avoid local irritation or tissue damage.
- Before injecting, check that the syringe is correctly loaded: a small drop of solution should appear at the needle tip. If not, discard the syringe and prepare a new one.
- Refer to sections E–G on pages 10–11 of the Product Leaflet for visual instruction, if available.
- Store the lyophilized powder refrigerated at 2–8 °C.
- After reconstitution, use within 7–14 days, keeping the solution refrigerated.
- Do not freeze. Protect from light.
Dosage Information
Triptorelin is extremely potent. Use with clinical-level caution.
HPTA Restart Protocol:
- Dose: 100 mcg one-time injection
- Timing: 1–2 weeks after last anabolic steroid dose
- Goal: Stimulate GnRH to reinitiate LH/FSH → endogenous testosterone production
Testosterone Suppression Protocol (TRT Pause):
- Dose: 100–500 mcg single injection
- Result: Suppresses LH/FSH for several weeks
- Used in TRT reset, pre-fertility, or hormonal control scenarios
Long-Acting Use (Advanced):
- Dosing frequency: Not more than 1 injection every 4–6 weeks
- Follow with HCG or Clomid if used in recovery context
Important Warnings
- Do not use in individuals with known hypersensitivity to GnRH analogues or any excipient in the formulation.
- Contraindicated in individuals with hormone-sensitive tumors unless medically indicated (e.g., androgen suppression in prostate cancer).
- Not recommended for use during pregnancy or breastfeeding due to potential hormonal disruption to fetal development.
- May cause an initial “flare” effect with elevated testosterone or estrogen levels during the first 1–2 weeks of use, which can temporarily worsen hormone-sensitive symptoms.
- Use with caution in patients with a history of depression, as mood changes may occur during suppression of sex hormones.
- May induce hypogonadism-like effects, such as reduced libido, fatigue, hot flashes, erectile dysfunction, and bone density loss if used long-term.
- Monitor reproductive hormone levels and pituitary-gonadal axis recovery after discontinuation, especially in PCT or hormone reset protocols.
- Avoid use in children or adolescents unless specifically prescribed in pediatric endocrinology settings.
- Always use sterile injection technique and follow proper dose timing, particularly when using in a low-dose PCT context.
- Medical supervision is strongly advised, especially when used for off-label hormone modulation.
Triptorelin
Triptorelin is a potent GnRH agonist peptide used to suppress or reset hormonal function by temporarily desensitizing the pituitary gland.
Key Ingredients
Triptorelin Acetate
Regulates Reproductive Health
Hormone Regulation
Boosts LH and FS release
Female Friendly
Not sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
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