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Peptides Line

VIP

Name: VIP
Brand: Peptalon
SKU: PE-139-01-5
Availability: InStock
Rating: 4.8 (127 reviews)

VIP (Vasoactive Intestinal Peptide) is a regulatory neuropeptide that plays a vital role in immune balance, gut-brain communication, and vascular health

From AED 200.00

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Key Ingredients

Vasoactive Intestinal Peptide

Anti inflammatory

Improves Blood Supply

Immune System Support

Supports Lung Health

Helps Digestion

Protect Braincells

Protects Against Free Radicals

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

VIP is a naturally occurring neuropeptide and hormone involved in numerous regulatory functions in the central nervous system, GI tract, immune system, and vascular tone. It is produced in the gut, pancreas, and brain, and acts as a key messenger in the gut-brain axis.

In therapeutic contexts, VIP has been shown to modulate cytokine release, support blood-brain barrier repair, reduce inflammatory signaling, and help restore immune homeostasis in complex conditions such as:

CIRS (Chronic Inflammatory Response Syndrome)
Mold exposure & biotoxin illness
Autoimmune neuroinflammation
Post-viral fatigue / long-COVID
Multiple chemical sensitivity (MCS)

It also improves gut motility, circadian rhythm, and cognitive clarity, making it one of the most promising peptides for integrative and functional medicine applications.

Scientific Background

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide first discovered in the 1970s, originally isolated from intestinal tissue. It is now known to be produced throughout the body—in the brain, gut, lungs, and immune system—where it acts as a powerful vasodilator, anti-inflammatory regulator, and immune-modulating messenger. VIP is part of the secretin-glucagon family and interacts with VPAC1 and VPAC2 receptors, activating cAMP pathways to promote smooth muscle relaxation, cytokine inhibition, and immune homeostasis.Mechanistically, VIP reduces TNF-α, IL-6, and other pro-inflammatory mediators, while increasing regulatory T-cell activity and supporting mucosal immunity, neuroprotection, and detoxification . It also plays a role in restoring circadian rhythm, modulating the HPA axis, and stabilizing the autonomic nervous system, particularly in conditions of environmental toxicity, Mold/CIRS, or neuroimmune dysregulation.

What Makes VIP Unique

Targets both immune and neurological systems simultaneously—ideal for complex, multi-system disorders
Acts through regulatory signaling, not immune suppression—making it suitable for chronic inflammatory or autoimmune settings
Shown to be protective for lungs, gut lining, vascular system, and brain
Highly effective in low doses and can be used nasally or subcutaneously for systemic effect
Especially valued in bioregulatory and functional medicine for detox, neuroinflammation, and immune reset protocols

Ideal for protocols addressing chronic inflammation, neuroimmune fatigue, environmental illness, and ANS dysregulation.

References

Delgado M, Ganea D. VIP and PACAP inhibit activation of NF-κB in macrophages through cAMP and PI3K-mediated pathways. Peptides. 2001;22(9):1443–1452. doi: 10.1016/S0196-9781(01)00494-2
Said SI. Vasoactive intestinal peptide in physiological and pathological processes. Curr Opin Endocrinol Diabetes Obes. 2007;14(1):61–66. doi: 10.1097/MED.0b013e328011f643

Usage Instructions

VIP is typically administered via nasal spray or subcutaneous injection, depending on formulation and therapeutic goal.

For Nasal Spray:

Shake gently before use
Apply 1–2 sprays per nostril, once or twice daily
Best taken morning and/or before bed depending on goal
Store refrigerated (2–8 °C) between uses
Do not share applicator

For Injection:

Reconstitute with bacteriostatic water
Inject subcutaneously, typically 100–200 mcg per dose
Administer in fasted state or before bed for systemic recovery

Dosage Information

Chronic Inflammation / CIRS Protocol:

Dose: 200 mcg nasal spray or injection 1–2× daily
Duration: 8–12 weeks, under guidance
Often paired with binders, antifungals, or detox support

Gut-Brain Support / Brain Fog Recovery:

Dose: 100–200 mcg once daily
Use in morning or early evening
May combine with BPC-157, Thymosin Alpha-1, or Semax

Neurological / Autoimmune Protocols:

Dose: 200 mcg per day (cycled 5 days on, 2 days off)
Duration: Long-term under supervision
Used in post-viral fatigue, mold exposure, or complex illness protocols

Important Warnings

Do not use in individuals with known hypersensitivity to VIP peptides or excipients in the formulation.
Use caution in patients with hypotension, as VIP is a potent vasodilator and may lower blood pressure significantly.
Not recommended during pregnancy or breastfeeding, due to lack of safety data.
Avoid use in individuals with adrenal insufficiency or uncontrolled autonomic dysfunction, as VIP may further affect vascular tone and electrolyte balance.
May interact with antihypertensive medications or vasoactive agents—monitor closely in clinical settings.
Mild side effects may include flushing, lightheadedness, headache, or nasal congestion, particularly when administered intranasally or intravenously.
Injectable use should follow aseptic technique, and dosing must be adjusted according to individual cardiovascular response.
Long-term use has not been widely studied outside clinical trials—use intermittent or pulse protocols when applying in wellness or longevity contexts.

Keep refrigerated (2–8 °C) and out of reach of children. Intended for research or therapeutic use under supervision.

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VIP is typically administered via nasal spray or subcutaneous injection, depending on formulation and therapeutic goal.

For Nasal Spray:

Shake gently before use
Apply 1–2 sprays per nostril, once or twice daily
Best taken morning and/or before bed depending on goal
Store refrigerated (2–8 °C) between uses
Do not share applicator

For Injection:

Reconstitute with bacteriostatic water
Inject subcutaneously, typically 100–200 mcg per dose
Administer in fasted state or before bed for systemic recovery

Dosage Information

Chronic Inflammation / CIRS Protocol:

Dose: 200 mcg nasal spray or injection 1–2× daily
Duration: 8–12 weeks, under guidance
Often paired with binders, antifungals, or detox support

Gut-Brain Support / Brain Fog Recovery:

Dose: 100–200 mcg once daily
Use in morning or early evening
May combine with BPC-157, Thymosin Alpha-1, or Semax

Neurological / Autoimmune Protocols:

Dose: 200 mcg per day (cycled 5 days on, 2 days off)
Duration: Long-term under supervision
Used in post-viral fatigue, mold exposure, or complex illness protocols

Important Warnings

Do not use in individuals with known hypersensitivity to VIP peptides or excipients in the formulation.
Use caution in patients with hypotension, as VIP is a potent vasodilator and may lower blood pressure significantly.
Not recommended during pregnancy or breastfeeding, due to lack of safety data.
Avoid use in individuals with adrenal insufficiency or uncontrolled autonomic dysfunction, as VIP may further affect vascular tone and electrolyte balance.
May interact with antihypertensive medications or vasoactive agents—monitor closely in clinical settings.
Mild side effects may include flushing, lightheadedness, headache, or nasal congestion, particularly when administered intranasally or intravenously.
Injectable use should follow aseptic technique, and dosing must be adjusted according to individual cardiovascular response.
Long-term use has not been widely studied outside clinical trials—use intermittent or pulse protocols when applying in wellness or longevity contexts.

Keep refrigerated (2–8 °C) and out of reach of children. Intended for research or therapeutic use under supervision.

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