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Peptides Line

Semax

Name: Semax
Brand: Peptalon
SKU: PE-0137-01-10
Availability: InStock
Rating: 4.8 (127 reviews)

Semax is a synthetic neuropeptide developed to improve focus, memory, learning, and brain resilience

From AED 230.00

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Key Ingredients

Semax Acetate

Enhances Memory

Boost Focus

Protect Braincells

Supports Neural Recovery

Relieve Stress

Elevate Mood

Improves Cerebral Blood Flow

Neuroprotection

Supports Brain Health

Product Information

Download product leaflet

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

Semax is a synthetic heptapeptide nootropic originally developed in Russia as a cognitive enhancer and stroke recovery agent. It improves mental stamina, attention span, andresilience to stress and fatigue by modulating dopamine, serotonin, and BDNF (brain-derived neurotrophic factor)pathways.

Unlike stimulant-based nootropics, Semax promotes focused mental clarity without causing jitteriness or crashes. It is mostly administered intranasally,delivering fast access to the central nervous system. Users report enhanced motivation, concentration, and mood regulation, especially under pressure or cognitive load.

Semax is non-addictive, non-sedating, and often used in peak performance, brain health, and post-burnout recovery protocols.

What Makes SEMAX Unique

Non-stimulant, rapid-acting nootropic
Enhances BDNF, dopamine, and cortical activation
Supports neuroregeneration, emotional balance, and mental endurance
Delivered via nasal spray or injection for high CNS bioavailability

Ideal for: mental performance, burnout recovery, stimulant tapering, and cognitive support during stress or dieting

Scientific Background

SEMAX is a synthetic neuroprotective peptide derived from a modified fragment of ACTH (4-10), engineered to retain neuromodulatory benefits without hormonal effects. Originally developed by the Russian Institute of Molecular Genetics, SEMAX was designed to treat cognitive impairment, ischemia, and stress-related neurological dysfunction.

Today, SEMAX is recognized for enhancing focus, memory, neuroplasticity, and mental stamina—without stimulant-related side effects or dependency.

Cognitive Enhancement & Neuroplasticity

SEMAX increases BDNF and NGF levels in the hippocampus and prefrontal cortex, supporting:

Memory formation
Synaptic plasticity
Neural regeneration after stress or trauma

Studies show improvements in working memory, attention, and learning speed, especially under mental fatigue or overload [1][2].

Anti-Fatigue & Dopaminergic Support

SEMAX modulates dopamine and serotonin, boosting motivation, alertness, and emotional stability. Clinically, it has been used in stroke recovery, ADHD-like symptoms, and chronic fatigue. Its stress-buffering effects make it valuable during burnout, sleep deprivation, or stimulant withdrawal.

Neuroprotection & Stress Recovery

SEMAX exhibits antioxidant and anti-inflammatory activity in the brain, modulating stress-response genes and protecting neurons from ischemic or oxidative damage. Its benefits extend to vascular health, making it useful post-concussion or during neurological recovery [3].

References

Ashmarin IP, Kamensky AA. The neurotropic and neuroprotective effects of Semax: a review. Neurosci Behav Physiol. 2005;35(9):941–948. doi: 10.1007/s11055-005-0187-7
Andreeva LA, et al. The efficacy of Semax in patients with mild cognitive disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(9):27–32. PMID: 17129908
Volobuev AI, et al. Semax prevents oxidative damage in the hippocampus after acute stress. Bull Exp Biol Med. 2007;143(4):431–434. doi: 10.1007/s10517-007-0221-y

Usage Instructions

Semax is most commonly delivered via nasal spray, which allows rapid CNS absorption.
If you have a injectable product please refer to the Leaflet delivered with your product.

Prime the spray pump before first use
Administer 1–2 sprays per nostril, 1–3× daily
Use during high cognitive load, learning, or peak performance phases
Do not exceed recommended dosage
Store refrigerated (2–8 °C) between uses

Dosage Information

Cognitive Enhancement / Focus Protocol:

Dose: 300–600 mcg per session
Frequency: 1–2× daily (morning or pre-task)
Duration: 10–30 days or used situationally

Burnout / Mental Recovery Use:

Dose: 400 mcg 2× daily
Use during fatigue, cognitive decline, or mood imbalance
Stack with NAD⁺, Selank, or mitochondrial peptides

Neuroprotective / Longevity Use:

Dose: 200–400 mcg once daily
Long-term use in cycles (e.g., 5 days on, 2 days off)

Important Warnings

For research use only – not approved for therapeutic applications.

Store nasal spray in the refrigerator (2–8 °C) when not in use.
Do not freeze.
Do not share nasal applicators.
Generally well tolerated.
Mild effects may include nasal irritation, restlessness, or slight headache in high doses.
Avoid use with dopamine antagonists.
Do not use continuously for extended periods without breaks.

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Today, SEMAX is recognized for enhancing focus, memory, neuroplasticity, and mental stamina—without stimulant-related side effects or dependency.

Cognitive Enhancement & Neuroplasticity

SEMAX increases BDNF and NGF levels in the hippocampus and prefrontal cortex, supporting:

Memory formation
Synaptic plasticity
Neural regeneration after stress or trauma

Studies show improvements in working memory, attention, and learning speed, especially under mental fatigue or overload [1][2].

Anti-Fatigue & Dopaminergic Support

Neuroprotection & Stress Recovery

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Semax