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Semax
Semax is a synthetic neuropeptide developed to improve focus, memory, learning, and brain resilience
Key Ingredients
Semax Acetate
Enhances Memory
Boost Focus
Protect Braincells
Supports Neural Recovery
Relieve Stress
Elevate Mood
Improves Cerebral Blood Flow
Neuroprotection
Supports Brain Health
Product Information
Download product leafletNot sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
Main Information
Semax is a synthetic heptapeptide nootropic originally developed in Russia as a cognitive enhancer and stroke recovery agent. It improves mental stamina, attention span, andresilience to stress and fatigue by modulating dopamine, serotonin, and BDNF (brain-derived neurotrophic factor)pathways.
Unlike stimulant-based nootropics, Semax promotes focused mental clarity without causing jitteriness or crashes. It is mostly administered intranasally,delivering fast access to the central nervous system. Users report enhanced motivation, concentration, and mood regulation, especially under pressure or cognitive load.
Semax is non-addictive, non-sedating, and often used in peak performance, brain health, and post-burnout recovery protocols.
What Makes SEMAX Unique
- Non-stimulant, rapid-acting nootropic
- Enhances BDNF, dopamine, and cortical activation
- Supports neuroregeneration, emotional balance, and mental endurance
- Delivered via nasal spray or injection for high CNS bioavailability
Ideal for: mental performance, burnout recovery, stimulant tapering, and cognitive support during stress or dieting
Scientific Background
SEMAX is a synthetic neuroprotective peptide derived from a modified fragment of ACTH (4-10), engineered to retain neuromodulatory benefits without hormonal effects. Originally developed by the Russian Institute of Molecular Genetics, SEMAX was designed to treat cognitive impairment, ischemia, and stress-related neurological dysfunction.
Today, SEMAX is recognized for enhancing focus, memory, neuroplasticity, and mental stamina—without stimulant-related side effects or dependency.
Cognitive Enhancement & Neuroplasticity
SEMAX increases BDNF and NGF levels in the hippocampus and prefrontal cortex, supporting:
- Memory formation
- Synaptic plasticity
- Neural regeneration after stress or trauma
Studies show improvements in working memory, attention, and learning speed, especially under mental fatigue or overload [1][2].
Anti-Fatigue & Dopaminergic Support
SEMAX modulates dopamine and serotonin, boosting motivation, alertness, and emotional stability. Clinically, it has been used in stroke recovery, ADHD-like symptoms, and chronic fatigue. Its stress-buffering effects make it valuable during burnout, sleep deprivation, or stimulant withdrawal.
Neuroprotection & Stress Recovery
SEMAX exhibits antioxidant and anti-inflammatory activity in the brain, modulating stress-response genes and protecting neurons from ischemic or oxidative damage. Its benefits extend to vascular health, making it useful post-concussion or during neurological recovery [3].
References
Ashmarin IP, Kamensky AA. The neurotropic and neuroprotective effects of Semax: a review. Neurosci Behav Physiol. 2005;35(9):941–948. doi: 10.1007/s11055-005-0187-7
Andreeva LA, et al. The efficacy of Semax in patients with mild cognitive disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(9):27–32. PMID: 17129908
Volobuev AI, et al. Semax prevents oxidative damage in the hippocampus after acute stress. Bull Exp Biol Med. 2007;143(4):431–434. doi: 10.1007/s10517-007-0221-y
Usage Instructions
Semax is most commonly delivered via nasal spray, which allows rapid CNS absorption.
If you have a injectable product please refer to the Leaflet delivered with your product.
- Prime the spray pump before first use
- Administer 1–2 sprays per nostril, 1–3× daily
- Use during high cognitive load, learning, or peak performance phases
- Do not exceed recommended dosage
- Store refrigerated (2–8 °C) between uses
Dosage Information
Cognitive Enhancement / Focus Protocol:
- Dose: 300–600 mcg per session
- Frequency: 1–2× daily (morning or pre-task)
- Duration: 10–30 days or used situationally
Burnout / Mental Recovery Use:
- Dose: 400 mcg 2× daily
- Use during fatigue, cognitive decline, or mood imbalance
- Stack with NAD⁺, Selank, or mitochondrial peptides
Neuroprotective / Longevity Use:
- Dose: 200–400 mcg once daily
- Long-term use in cycles (e.g., 5 days on, 2 days off)
Important Warnings
- For research use only – not approved for therapeutic applications.
- Store nasal spray in the refrigerator (2–8 °C) when not in use.
- Do not freeze.
- Do not share nasal applicators.
- Generally well tolerated.
- Mild effects may include nasal irritation, restlessness, or slight headache in high doses.
- Avoid use with dopamine antagonists.
- Do not use continuously for extended periods without breaks.
Semax
Semax is a synthetic neuropeptide developed to improve focus, memory, learning, and brain resilience
Key Ingredients
Semax Acetate
Enhances Memory
Boost Focus
Protect Braincells
Supports Neural Recovery
Relieve Stress
Elevate Mood
Improves Cerebral Blood Flow
Neuroprotection
Supports Brain Health
Product Information
Download product leafletNot sure about the right dosage?
Use our Peptide Dosage Calculator for optimal application
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